Peyronie’s Disease

XIAFLEX® Injections

A curved erection caused by Peyronie's disease may happen because of a problem in the way the body heals after an injury (a connective tissue disorder).

When this happens, the body doesn't properly control how much scar tissue develops and too much builds up gradually. A bump of scar tissue forms under the skin of the penis. This bump is called a Peyronie's plaque.

Peyronie's disease is unlikely to go away on its own, and may get worse over time.

Erectile curvature can vary greatly from man to man. You could have Peyronie's disease with a curve ranging anywhere from 15 degrees to more than 90 degrees.

XIALFEX® is administered via injection into the penis, and is indicated to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.

Risks of Procedure

  • Penile fracture (corporal rupture) or other serious injury to the penis, indicated by:
    • a popping sound or sensation in an erect penis
    • sudden loss of the ability to maintain an erection
    • pain in your penis
    • purple bruising and swelling of your penis
    • difficulty urinating or blood in the urine
  • Hypersensitivity reactions, including anaphylaxis, indicated by:
    • hives
    • swollen face
    • breathing trouble
    • chest pain
    • low blood pressure
    • dizziness or fainting

Important Information

  • DO NOT receive XIAFLEX® injections if you have been told by your healthcare provider that the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra)
  • DO NOT receive XIAFLEX® injections if you are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®